| 产品详情 |
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| Antigenic Specificity | MCL-1 |
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| Clone | LVUBKM |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, kappa |
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| Format | Alexa Fluor 488 conjugate |
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| Size | 100 Tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 5 µL (0.125 µg)/test |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MCL-1 Monoclonal Antibody (LVUBKM), Alexa Fluor 488, eBioscience™. Mcl-1 (Myeloid cell leukemia-1) is a member of the bcl-2 family. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g. ionizing radiation, ultraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. |
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| Immunogen | n/a |
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| Other Names | bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related) |
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| Gene, Accession # | Entrez: 17210, 4170; Uniprot: P97287, Q07820 |
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| Catalog # | 53-9047-42 |
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| Price | |
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| Order / More Info | MCL-1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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