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| Product Name | Recombinant Human Tumor necrosis factor ligand superfamily member 13B protein (TNFSF13B) (Active) |
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| Description | Purity > 95% as determined by SDS-PAGE and HPLC. MW: 17.2kDa. Partial: 234-285aa. tag-Free. Homo sapiens (Human). Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000250}.; Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | B lymphocyte stimulator, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1 |
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| Gene, Accession, CAS # | TNFSF13B,BAFF,BLYS,TALL1,TNFSF20,ZTNF4,UNQ401/PRO738, UniProt: Q9Y275 |
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| Catalog # | RPC26708 |
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| Order / More Info | Recombinant Human Tumor necrosis factor ligand superfamily member 13B protein (TNFSF13B) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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