| 产品详情 |
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| Antigenic Specificity | hnRNP-K |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 20 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 1:100-1:400, Western Blot: 1:1,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | hnRNP-K Polyclonal Antibody. One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction By similarity. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction |
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| Immunogen | n/a |
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| Other Names | CSBP, TUNP, dC-stretch binding protein |
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| Gene, Accession # | Entrez: 15387, 3190; Uniprot: P61978, P61979 |
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| Catalog # | A300-674A-T |
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| Price | |
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| Order / More Info | hnRNP-K Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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