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| Product Name | Recombinant Human Cell cycle checkpoint protein RAD1 (RAD1) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 58.8kDa. Full Length: 1-282aa. N-terminal GST-tagged. Homo sapiens (Human). Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | DNA repair exonuclease rad1 homolog; Rad1-like DNA damage checkpoint protein |
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| Gene, Accession, CAS # | RAD1, UniProt: O60671 |
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| Catalog # | RPC21901 |
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| Order / More Info | Recombinant Human Cell cycle checkpoint protein RAD1 (RAD1) from BIOMATIK |
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| Product Specific References | n/a |
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