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| Antigenic Specificity | IRF8 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Flow Cytometry: 1:10-1:50, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRF8 Polyclonal Antibody. IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B. |
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| Immunogen | n/a |
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| Other Names | Interferon regulatory factor 8; IRF-8; Interferon consensus sequence-binding protein; ICSBP; IRF8; ICSBP1 |
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| Gene, Accession # | Entrez: 3394; Uniprot: Q02556 |
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| Catalog # | PA5-12440 |
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| Price | |
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| Order / More Info | IRF8 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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