| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | IRF8 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunoprecipitation: 2-10 µg/mg lysate |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | IRF8 Polyclonal Antibody. IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B. |
|---|
| Immunogen | n/a |
|---|
| Other Names | H-ICSBP, ICSBP, ICSBP1, IRF-8 |
|---|
| Gene, Accession # | Entrez: 15900; Uniprot: P23611 |
|---|
| Catalog # | A304-026A |
|---|
| Price | |
|---|
| Order / More Info | IRF8 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|