| 产品详情 |
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| Antigenic Specificity | BACE1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 0.5 -1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | BACE1 Polyclonal Antibody. Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl pr |
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| Immunogen | n/a |
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| Other Names | beta Secretase 1 |
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| Gene, Accession # | Entrez: 23621, 23821; Uniprot: P56817, P56818 |
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| Catalog # | PA1-12529 |
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| Price | |
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| Order / More Info | BACE1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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