| 产品详情 |
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| Antigenic Specificity | Cullin 4A |
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| Clone | GT885 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Western Blot: 1:5000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cullin 4A Monoclonal Antibody (GT885). CUL4a is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquit |
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| Immunogen | n/a |
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| Other Names | CUL-4A, CUL4A, Cullin 4a |
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| Gene, Accession # | Entrez: 8451; Uniprot: Q13619 |
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| Catalog # | MA5-27796 |
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| Price | |
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| Order / More Info | Cullin 4A Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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