| 产品详情 |
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| Antigenic Specificity | Cullin 4A |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA: 1:1000-1:5000, Immunohistochemistry (Paraffin): 1:25-1:100, Western Blot: 1:1000-1:5000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cullin 4A Polyclonal Antibody. CUL4a is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination |
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| Immunogen | n/a |
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| Other Names | cullin 4A |
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| Gene, Accession # | Entrez: 8451, 99375; Uniprot: Q13619, Q3TCH7 |
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| Catalog # | PA5-49716 |
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| Price | |
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| Order / More Info | Cullin 4A Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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