| 产品详情 |
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| Antigenic Specificity | Cullin 4B |
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| Clone | OTI7F8 |
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| Host Species | Mouse |
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| Reactive Species | canine, human, mouse, nonhuman primate, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cullin 4B Monoclonal Antibody (OTI7F8). Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repa |
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| Immunogen | n/a |
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| Other Names | MRXHF2, MRXS15, MRXSC, SFM2, CUL-4B, cullin-4B |
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| Gene, Accession # | Entrez: 302502, 492102, 696410, 72584, 8450; Uniprot: A2A432, Q13620 |
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| Catalog # | MA5-26436 |
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| Price | |
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| Order / More Info | Cullin 4B Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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