| 产品详情 |
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| Antigenic Specificity | RIG-I |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 5 µg/mL, Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RIG-I Polyclonal Antibody. The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKK-iota through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus. |
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| Immunogen | n/a |
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| Other Names | RIG-I; DEAD box protein 58; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; RIG-1; RNA helicase RIG-I; probable ATP-dependent RNA helicase DDX58; retinoic acid inducible gene I; retinoic acid-inducible gene 1 protein; retinoic acid-inducible gene I protein |
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| Gene, Accession # | Entrez: 230073, 23586, 297989; Uniprot: O95786, Q6Q899 |
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| Catalog # | PA5-20276 |
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| Price | |
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| Order / More Info | RIG-I Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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