| 产品详情 |
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| Antigenic Specificity | TICAM1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit polyclonal to TICAM1. TIR domain-containing adapter molecule 1 (TICAM1) is Involved in innate immunity against invading pathogens. TICAM1 is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1; which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD, respectively. TICAM1 is ubiquitously expressed with higher levels observed in liver. |
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| Immunogen | N-terminal region of human TICAM1 |
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| Other Names | TIR domain-containing adapter molecule 1, TICAM-1, Proline-rich, vinculin and TIR domain-containing protein B, Putative NF-kappa-B-activating protein 502H, PRVTIRB, TRIF, TRIP |
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| Gene, Accession # | UniProt: Q8IUC6 |
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| Catalog # | orb107116 |
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| Price | |
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| Order / More Info | TICAM1 Antibody from BIORBYT LTD. |
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| Product Specific References | n/a |
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