| 产品详情 |
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| Antigenic Specificity | ASAH2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1-4 µg/mL, Immunofluorescence: 1-4 µg/mL, Immunohistochemistry: 1:1000-1:2500, Western Blot: 0.4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ASAH2 Polyclonal Antibody. Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functio |
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| Immunogen | n/a |
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| Other Names | BCDase, HNAC1, LCDase, N-CDase, NCDase; N-acylsphingosine amidohydrolase 2; acylsphingosine deacylase 2; mitochondrial ceramidase; neutral ceramidase; neutral/alkaline ceramidase; non-lysosomal ceramidase |
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| Gene, Accession # | Entrez: 56624; Uniprot: Q9NR71 |
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| Catalog # | PA5-63928 |
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| Price | |
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| Order / More Info | ASAH2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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