| 产品详情 |
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| Antigenic Specificity | FKBP5 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | canine, hamster, human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FKBP5 Polyclonal Antibody. Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As P |
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| Immunogen | n/a |
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| Other Names | FK506 Binding Protein 51, EC 5.2.1.8, Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase, 51 kDa FK506-binding protein, 54 kDa progesterone recepto |
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| Gene, Accession # | Entrez: 100760904, 14229, 2289, 361810, 481759; Uniprot: Q13451, Q64378 |
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| Catalog # | PA1-020 |
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| Price | |
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| Order / More Info | FKBP5 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 11751894, 14744870, 15199065, 15697228, 15745951, 16002417, 17176100, 20038533, 20796173, 20819118, 26037418, 27844058, 9125197 |
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