| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | RIP1 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 ug |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry: 5-10 µg/mL |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | RIP1 Polyclonal Antibody. RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, |
|---|
| Immunogen | n/a |
|---|
| Other Names | RIP1 (CT), Receptor-interacting serine/threonine-protein kinase 1, RIP, RIPK1 |
|---|
| Gene, Accession # | Entrez: 8737; Uniprot: Q13546 |
|---|
| Catalog # | PA5-34556 |
|---|
| Price | |
|---|
| Order / More Info | RIP1 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|