| 产品详情 |
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| Antigenic Specificity | RIP1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RIP1 Polyclonal Antibody. RIPK1 (Receptor Interacting Protein) is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIPK1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIPK1 is important for signallling to NFkappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIPK1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIPK1-deficient mice fail to thrive, displaying extens |
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| Immunogen | n/a |
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| Other Names | RIP, RIP1; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; serine/threonine-protein kinase RIP |
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| Gene, Accession # | Entrez: 19766, 306886, 8737; Uniprot: Q13546, Q60855 |
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| Catalog # | PA5-20811 |
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| Price | |
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| Order / More Info | RIP1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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