| 产品详情 |
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| Antigenic Specificity | Nicastrin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, nonhuman primate, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Nicastrin Polyclonal Antibody. This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not |
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| Immunogen | n/a |
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| Other Names | ATAG1874; OTTHUMP00000031840; anterior pharynx-defective 2 |
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| Gene, Accession # | Entrez: 23385, 289231, 59287; Uniprot: P57716, Q8CGU6, Q92542 |
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| Catalog # | PA5-17735 |
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| Price | |
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| Order / More Info | Nicastrin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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