| 产品详情 |
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| Product Name | PKF118-310 |
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| Description | An inhibitor of the Tcf4-β-catenin protein interaction; disrupts binding of β-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM); blocks appearance of the Tcf4 and β-catenin complex bound to DNA in an EMSA assay; reduces levels of the β-catenin regulated proteins c-Myc and cyclin D1 in HCT116 cells; reduces growth of HCT116, HT-29, PC3, and DU145 cancer cells in vitro (IC50s = 170-300 nM); reduces tumor growth and expression of c-Myc, cyclin D1, and Survivin in a HepG2 mouse xenograft model (1 mg/kg twice per week) |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | NSC 67078|Toxoflavin |
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| Gene, Accession, CAS # | CAS: 84-82-2 |
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| Catalog # | 22440-5 |
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| Price | |
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| Order / More Info | PKF118-310 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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