| 产品详情 |
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| Antigenic Specificity | XAF1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:10-1:500, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | XAF1 Polyclonal Antibody. The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines. |
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| Immunogen | n/a |
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| Other Names | BIRC4BP, HSXIAPAF1, XIAPAF1 |
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| Gene, Accession # | Entrez: 327959, 54739; Uniprot: Q5NBU8, Q6GPH4 |
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| Catalog # | PA1-41099 |
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| Price | |
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| Order / More Info | XAF1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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