| 产品详情 |
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| Product Name | Ubiquitin Specific Peptidase 28 (USP28) protein (His tag) |
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| Description | USP28 is a deubiquitinating enzyme of the C19 peptidase family that regulates MYC stability and DNA damage response checkpoints. USP28 regulates DNA repair by deubiquitinating and thereby stabilizing CLSPN, a protein that is ubiquitinated by the APC/C E3 ubiquitin ligase in a cell-cycle dependent manner. USP28 interacts with isoform 1 of FBXW7 in the nucleoplasm, and regulates MYC degradation by counteracting its ubiquitination. A potential role in HIF-1alpha-dependent processes such as angiogenesis and metastasis has been described for this deubiquitinase. USP28 has been demonstrated to cleave K6, K11, K48, and K63-linked poly-ubiquitin chains. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | im:7138195|USP28|9830148O20Rik|AU022237|mKIAA1515 |
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| Gene, Accession, CAS # | Gene ID: 57646 |
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| Catalog # | ABIN2746000 |
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| Order / More Info | Ubiquitin Specific Peptidase 28 (USP28) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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| 产品资料 |
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