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| Product Name | Proteinase 3, Human (PRTN3, Neutrophil) |
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| Description | Highly Purified (~95%). Proteinase 3 also known as PRTN3 is an enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis. Anti-neutrophil cytoplasmic antibodies (ANCAs) are autoantibodies produced in response to neutrophil cytoplasmic enzymes, and evaluating the levels of ANCAs is useful for making a diagnosis of systemic vasculitis such as granulomatosis with polyangiitis (Wegener's) (GPA) or microscopic polyarteritis (MPA). The majority of p-ANCAs and c-ANCAs have been proven to be equivalent to MPO- and PR3- ANCAs, respectively. Patients with MPA and Churg- Strauss syndrome are positive for p-ANCA, and those with GPA are positive for c- |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 209162 |
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| Order / More Info | Proteinase 3, Human (PRTN3, Neutrophil) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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