| 产品详情 |
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| Product Name | 4-Methylhistamine (hydrochloride) |
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| Description | A histamine H4 receptor agonist (Ki = 50 nM); >100-fold selective for H4 over other histamine receptors; inhibits forskolin-induced CRE-β-galactosidase activity in SK-N-MC cells transfected with the human H4 receptor (EC50 = 39.8 nM); induces a change in eosinophil shape (EC50 = 0.36 µM) and stimulates migration of murine bone marrow mast cells (EC50 = 12 µM); reduces airway resistance and inflammation and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of allergic asthma when administered intratracheally at a dose of 10 µg/animal; reduces epidermal hyperplasis, hyperkeratosis, and lymphocyte infiltration and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of imiquimod-induced psoriasis |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 36507-31-0 H-4 SKNMC JNJ7777120 CD-4 25 Fox-P3 |
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| Gene, Accession, CAS # | CAS: 36376-47-3 |
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| Catalog # | 23761-5 |
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| Order / More Info | 4-Methylhistamine (hydrochloride) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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