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| Product Name | PSEM3, Recombinant, Human, aa1-254, His-Tag |
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| Description | Purity ~90% (SDS-PAGE). PSME3 (Proteasome activator complex subunit 3) belongs to the PA28 family. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSEM3 facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Source: Recombinant corresponding to aa1-254 from human PSME3, fused to His-tag at N-terminal expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MASLLKVDQE VKLKVDSFRE RITSEAEDLV ANFFPKKLLE LDSFLKEPIL NIHDLTQIHS DMNLPVP |
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| Size | 50ug, 250ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PSEM3, Recombinant, Human, aa1-254, His-Tag (Proteasome Activator Complex Subunit 3, 11S Regulator Complex Subunit gamma, REG-gamma, Activator of Multicatalytic Protease Subunit 3, Ki Nuclear Autoantigen, Proteasome Activator 28 Subunit gamma, PA28g, PA28gamma) |
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| Gene, Accession, CAS # | Accession: NP_005780 |
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| Catalog # | 29680 |
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| Order / More Info | PSEM3, Recombinant, Human, aa1-254, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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