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| Product Name | Recombinant Human Serine/threonine-protein kinase PLK1 (PLK1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 70.3kDa. Extracellular Domain: 1-603aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Activated by phosphorylation of Thr-210 by AURKA; phosphorylation by AURKA is enhanced by BORA. Once activated, activity is stimulated by binding target proteins. Binding of target proteins has no effect on the non-activated kinase. Several inhibitors targeting PLKs are currently in development and are under investigation in a growing number of clinical trials, such as BI 2536, an ATP-competitive PLK1 inhibitor or BI 6727, a dihydropteridinone that specifically inhibits the catalytic activity of PLK1. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13 |
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| Gene, Accession, CAS # | PLK1, UniProt: P53350 |
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| Catalog # | RPC20650 |
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| Order / More Info | Recombinant Human Serine/threonine-protein kinase PLK1 (PLK1), partial from BIOMATIK |
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| Product Specific References | n/a |
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