| 产品详情 |
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| Antigenic Specificity | HES6 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | canine, human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: 5 µg/mL, Western Blot: 1.25 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HES6 Polyclonal Antibody. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. |
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| Immunogen | n/a |
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| Other Names | Hairy and enhancer of split 6 (Drosophila), HES-6, bHLHb41, bHLHc23 |
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| Gene, Accession # | Entrez: 316626, 55502, 55927, 607298; Uniprot: Q96HZ4, Q9JHE6 |
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| Catalog # | PA5-40617 |
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| Price | |
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| Order / More Info | HES6 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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