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| Product Name | Human CellExp™ IL-23 R, Fc Tag, Human recombinant |
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| Description | Purity >95%. This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IL23R, IL-23 Receptor, Interleukin-23 receptor |
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| Gene, Accession, CAS # | IL23R, Gene ID: 149233, Accession: Q5VWK5 |
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| Catalog # | P1425-10 |
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| Price | |
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| Order / More Info | Human CellExp™ IL-23 R, Fc Tag, Human recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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