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| Product Name | Human CellExp™ LAIR1 / CD305, Fc Tag, Human Recombinant |
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| Description | Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell-mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and act |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | LAIR1, CD305 |
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| Gene, Accession, CAS # | LAIR1, Gene ID: 3903, Accession: Q6GTX8 |
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| Catalog # | P1239-50 |
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| Order / More Info | Human CellExp™ LAIR1 / CD305, Fc Tag, Human Recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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