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| Product Name | CD40 Ligand, soluble, Recombinant, Human |
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| Description | Purity ~98% by SDS-PAGE and HPLC. Endotoxin: ≤ 0.1ng/ug (1EU/ug). Recombinant human soluble CD40 ligand is a 16.3kD protein containing 149aa residues comprising the receptor binding TNF-like domain of CD40L. CD40 is a member of the TNF receptor family. it is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to ?immunodeficiency with hyper-IgM, a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261aa type II transmembrane protein, which contains a 22aa cytoplasmic domain, a 24aa transmembrane domain and a 215aa extracellular domain. The soluble form of CD40L is an 18kD protein compri |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD40 Ligand, soluble, Recombinant, Human (CD40 Ligand, CD40-L, CD40L, CD40LG, hCD40L, sCD40L, CD178, gp39, HIGM1, IGM, IMD3, T-BAM, T-cell Antigen GP39, TNF-related Activation Protein, TRAP, Tumor Necrosis Factor Ligand Superfamily Member 5, TNF Ligand Superfamily Member 5, TNFSF5) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2392-30 |
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| Order / More Info | CD40 Ligand, soluble, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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