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| Product Name | Recombinant Human Estrogen receptor beta (ESR2), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 51.9kDa. Partial of Isoform 3: 2-323aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | ER-beta; Alternative name (s); Nuclear receptor subfamily 3 group A member 2 |
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| Gene, Accession, CAS # | ESR2, UniProt: Q92731 |
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| Catalog # | RPC21282 |
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| Order / More Info | Recombinant Human Estrogen receptor beta (ESR2), partial from BIOMATIK |
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| Product Specific References | n/a |
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