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| Product Name | Recombinant Human Estrogen receptor (ESR1), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 67.2kDa. Partial: 10-595aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response elent (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response elent of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elents; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates mbrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1 |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | ER-alphaEstradiol receptor; Nuclear receptor subfamily 3 group A member 1 |
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| Gene, Accession, CAS # | ESR1, UniProt: P03372 |
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| Catalog # | RPC24652 |
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| Order / More Info | Recombinant Human Estrogen receptor (ESR1), partial from BIOMATIK |
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| Product Specific References | n/a |
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