| 产品详情 |
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| Product Name | Prucalopride |
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| Description | A potent and selective 5-HT4 agonist (Ki = 2.5 and 8 nM for 5-HT4A and 5-HT4B, respectively); greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human D4 and σ1 receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 µM respectively); induces 5-HT4-dependent contractions in guinea pig colon (EC50 = 33 nM) and facilitates non-cholinergic contractions induced by electrical stimulation; increases colonic motility by inhibiting distal colon contractions in dogs (ED50 = 0.04 mg/kg, p.o.); increases acetylcholine and histamine levels in the rat prefrontal cortex and the power of hippocampal theta oscillations (5-10 mg/kg, s.c.) |
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| Size | 100 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Resolor R-093877 5HT4 5HT-2A 3 4 4B 4A noncholinergic GR-125487 113808 5HT2A 5HT3 5HT4 5HT4B R093877 5HT4A D-4 σ-1 |
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| Gene, Accession, CAS # | CAS: 179474-81-8 |
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| Catalog # | 24192-100 |
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| Price | |
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| Order / More Info | Prucalopride from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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