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| Product Name | Recombinant Human GTP-binding nuclear protein Ran (RAN) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 51.3kDa. Full Length: 1-216aa. N-terminal GST-tagged. Homo sapiens (Human). GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein |
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| Gene, Accession, CAS # | RAN, UniProt: P62826 |
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| Catalog # | RPC21906 |
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| Order / More Info | Recombinant Human GTP-binding nuclear protein Ran (RAN) from BIOMATIK |
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| Product Specific References | n/a |
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