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| Product Name | Recombinant Mouse Dedicator of cytokinesis protein 8 (Dock8), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 55.8kDa. Partial: 1633-2067aa. N-terminal 6xHis-tagged. Mus musculus (Mouse). Guanine nucleotide exchange factor which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center, and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Dock8, UniProt: Q8C147 |
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| Catalog # | RPC26078 |
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| Price | |
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| Order / More Info | Recombinant Mouse Dedicator of cytokinesis protein 8 (Dock8), partial from BIOMATIK |
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| Product Specific References | n/a |
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