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| Product Name | Mubritinib, Free Base |
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| Description | Purity ~99%. Mubritinib is a potent inhibitor of the human epidermal growth factor receptor 2 (HER2) tyrosine kinase. For inhibitory testing, HER2 was expressed in the following cell types: bladder (HT1376, UMUC3, T24), kidney (ACHN), and prostate (DU145, LNCaP, LN-REC4). IC50 values for mubritinib for the bladder cancer cell lines varied from 0.09 uM to greater than 25 uM. All of the prostate cancer cell lines studied were sensitive (IC50=0.053-4.6 uM) to mubritinib, but ACHN cells were relatively less sensitive. In the xenograft model, treatment with mubritinib for 14 days significantly inhibited growth of UMUC-3 (22.9%), ACHN (26.0%), and LN-REC4 (26.5%) when compared to control. Solubility: Soluble in DMSO at 25mg/ml with warming; soluble in ethanol at 1.7mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mubritinib, Free Base (1-[4-[4-[[2-[(1E)-2-[4-(Trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole, TAK-165, D04025) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M9202-50 |
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| Price | |
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| Order / More Info | Mubritinib, Free Base from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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