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| Product Name | Recombinant Human papillomavirus type 16 Protein E7 (E7) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 13.0kDa. Full Length: 1-98aa. N-terminal 6xHis-tagged. Human papillomavirus type 16. Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | n/a |
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| Gene, Accession, CAS # | E7, UniProt: P03129 |
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| Catalog # | RPC26158 |
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| Order / More Info | Recombinant Human papillomavirus type 16 Protein E7 (E7) from BIOMATIK |
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| Product Specific References | n/a |
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