| 产品详情 |
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| Product Name | mu delta Opiod Receptor Agonist, CYM51010 |
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| Description | Purity ~90% (HPLC). A cell-permeable, blood-brain barrier permeant, non-toxic phenethylpiperidine compound that binds reversibly and with high affinity to the uOR-deltaOR-heteromer. Exhibits a robust beta-arrestin recruitment activity (EC50 = 8.3uM; Emax = 1,197% over basal), which is at least two to three-fold higher than that obtained with ubetagalOR (EC50 = 1.8uM; Emax = 557%) or deltabetagalOR (EC50 = 2.7uM; Emax = 423%) alone. Induces a strong increase in [35S]GTPupsilonS binding (EC50 = 54, 210, and 300nM; and Emax (% basal) = 168, 138 and 113 for with ubetagalOR-deltaOR, ubetagalOR and deltabetagalOR, respectively). Potentiates antinociceptive activity similar to morphine (10mg/kg, s.c. in a tail-flick assay) with less side effects and dependency. However, chronic administration of CYM51010 results in reduced antinociceptive tolerance compared with morphine. Solubility: DMSO Primary Target: muOR-deltaOR-heteromer |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | mu delta Opiod Receptor Agonist, CYM51010 (CID23723457, CYM-51010, ML335, Opiod Receptor Ligand, Ethyl-1-(4-acetamidobenzyl)-4-phenethylpiperidine-4-carboxylate, Ethyl-1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate, Ethyl 1-(4-(acetylamino)benzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217573 |
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| Order / More Info | mu delta Opiod Receptor Agonist, CYM51010 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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