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| Product Name | A-366 |
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| Description | Purity >98%. A-366 is a potent, peptide-competitive inhibitor of the lysine methyltransferase G9a (IC50 = 3.3 nM). It displays greater than 1,000-fold selectivity over 21 other methyltransferases. A-366 significantly reduces the cellular levels of dimethylation on histone 3 at lysine 9 (H3K9Me2) in PC3 cells without reducing total histone 3, H3K27Me3, or H3K36Me2. It also blocks the interaction of the methyl lysine reader protein Spindlin1 with H3K4me3 by binding with a Spindlin1 Tudor domain (Kd = 111 nM). See the Structural Genomics Consortium (SGC) website for more information. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-spiro[cyclobutane-1,3'-[3H]indol]-2'-amine |
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| Gene, Accession, CAS # | CAS: 1527503-11-2 |
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| Catalog # | LS-H6348 |
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| Order / More Info | A-366 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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