| 产品详情 |
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| Product Name | A-771726 |
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| Description | Purity >98%. A-771726 is the active metabolite of leflunomide, a prodrug approved by the FDA for treatment of rheumatoid arthritis. A-771726 reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines. It prevents activated lymphocytes from accumulating sufficient pyrimidines to support DNA synthesis (IC50 s = 0.09, 3.5, and 12.5 µM for rat, mouse, and human, respectively). At higher doses, A-771726 inhibits tyrosine kinases responsible for early T cell and B cell signaling in the G0 /G1 phase of the cell cycle. A-771726 has also been shown to inhibit the production of prostaglandin E2 in synoviocytes activated by TNF-Alpha and IL-1Alpha (IC50 s = 7 and 3 µM, respectively) as well as inhibit MMP-1 and IL-6 production at concentrations >10 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2Z-butenamide, Flucyamide, HMR 1726, SU 20, Teriflunomide |
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| Gene, Accession, CAS # | CAS: 163451-81-8 |
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| Catalog # | LS-H6362 |
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| Order / More Info | A-771726 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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