| 产品详情 |
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| Product Name | A 1210477 |
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| Description | Selective, high affinity Mcl-1 inhibitor (Ki = 454 pM). Disrupts Mcl-BIM complexes (IC50 in low μM range). Also inhibits Mcl-1NOXA interactions. Exhibits no effect on Bcl-XL-Bim or Bcl-X-BCL-Xs interactions. Induces apoptosis in multiple myeloma and non-small cell lung cancer cell lines and exhibits a synergistic effect with NavitoclaxTM to induce apoptosis in vitro. Cell permeable. Purity 98%. MW (observed): 850.04 |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid |
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| Gene, Accession, CAS # | CAS: 1668553-26-1 |
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| Catalog # | 6409/5 |
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| Price | |
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| Order / More Info | A 1210477 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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