| 产品详情 |
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| Product Name | A 485 |
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| Description | Potent and selective p300/CREB-binding protein (CBP) HAT domain inhibitor (IC50 values are 2.6 and 9.8 nM for the CBP-bromodomain HAT-C/H3 (BHC) and p300-BHC domains, respectively). Displays > 1000-fold selectivity over closely related HATs. Suppresses proliferation in several hematological malignancies and AR+ prostate cancer cell lines in vitro. Inhibits tumor growth in a castration-resistant prostate cancer xenograft model. Orally bioavailable. To request the negative control for A 485, please fill out the A 486 request form on the SGC website.. Purity 98%. MW (observed): 536.48 |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1R)-N-[(4-Fluorophenyl)methyl]-2,3-dihydro-5-[[(methylamino)carbonyl]amino]-2',4'-dioxo-N-[(1S)-2,2,2-trifluoro-1-methylethyl]spiro[1H-indene-1,5'-oxazolidine]-3'-acetamide |
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| Gene, Accession, CAS # | CAS: 1889279-16-6 |
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| Catalog # | 6387/25 |
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| Price | |
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| Order / More Info | A 485 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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| 产品资料 |
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