| 产品详情 |
| Edit |   |
|---|
| Product Name | TMI 1 |
|---|
| Description | Adam 17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable. Purity 98%. MW (observed): 398.49 |
|---|
| Size | 50 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide |
|---|
| Gene, Accession, CAS # | CAS: 287403-39-8 |
|---|
| Catalog # | 5960/50 |
|---|
| Price | |
|---|
| Order / More Info | TMI 1 from TOCRIS BIOSCIENCE
|
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|