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| Antigenic Specificity | Phospho-SMAD3 (Ser213) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-SMAD3 (Ser213) Polyclonal Antibody. SMAD3, a receptor regulated SMAD (R-SMAD) is a transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is estimated to account for at least 80% of all TGF-beta-mediated response. Activated type I receptor phosphorylates receptor-activated SMADS (RSMADS) at their c-terminal two extreme serines in the SSXS motif. The phosphorylated R-SMAD translocate into nucleus, where they regulate transcription of target genes. SMAD3 signal transduction appears to be important in the rgulation of muscle-specific genes. Loss of SMAD3 is a feature of pediatric T-cell lymphoblastic leukemia, while upregulation of SMAD3 may be responsible for TGFB hyperre |
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| Immunogen | n/a |
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| Other Names | Mothers against decapentaplegic homolog 3; SMAD 3; Mothers against DPP homolog 3; Mad3; hMAD-3; JV15-2; hSMAD3; SMAD3; MADH3; |
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| Gene, Accession # | Entrez: 4088; Uniprot: P84022 |
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| Catalog # | PA5-12694 |
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| Price | |
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| Order / More Info | Phospho-SMAD3 (Ser213) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 26648552 |
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