| 产品详情 |
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| Antigenic Specificity | Phospho-SMAD2 (Ser465, Ser467) |
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| Clone | H.205.4 |
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| Host Species | Rabbit |
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| Reactive Species | human, mink, mouse, rat |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Western Blot: 1:1000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-SMAD2 (Ser465, Ser467) Monoclonal Antibody (H.205.4). SMAD2 (MADH2, MAD2) regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK1) enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. In response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association w |
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| Immunogen | n/a |
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| Other Names | MAD homolog 2; MAD, mothers against decapentaplegic homolog 2; Mad protein homolog; Mad, mothers against decapentaplegic homolog 2; Mad-related protein 2; SMAD 2; SMAD, mothers against DPP homolog 2; Sma- and Mad-related protein 2; mother against DPP homolog 2; mothers against DPP homolog 2; mothers against decapentaplegic homolog 2, pSMAD2 |
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| Gene, Accession # | Entrez: 17126, 29357, 4087; Uniprot: O70436, Q15796, Q62432 |
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| Catalog # | MA5-15122 |
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| Price | |
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| Order / More Info | Phospho-SMAD2 (Ser465, Ser467) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 27653144 |
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