| 产品详情 |
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| Antigenic Specificity | ZO-2, Human |
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| Clone | polyclonal |
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| Host Species | Guinea |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | 100 µg/ml |
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| Applications | frozen sections, IF, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The polyclonal antibody recognizes human zona occludens 2 (ZO-2), an ~160 kDa tight junction protein belonging to the membrane-associated guanlyate kinase (MAGUK) family. Members of this family are involved in epithelial and endothelial intercellular junctions. They each contain at least one PSD95/Dlg/ZO-1 (PDZ) domain, a Src homology 3 (SH3) domain, and an enzymatically inactive guanylate kinase domain. PDZ domains are 90-amino acid protein-protein binding domains that recognize at least a 3-residue peptide motif in the COOH termini of their binding partners. PDZ domain-containing proteins, like ZO-2, typically act as scaffolding proteins that organize membrane receptors and cytosolic proteins into multimeric signaling complexes often at the sites of cell-cell contact. The effectiveness and stability of the epithelial barrier depends on a complex of proteins composing different intercellular junctions, which include tight junctions, adherens junctions, and desmosomes. ZO-2 can interact with zona occludens 1 (ZO-1). Furthermore, the PDZ2 domain of ZO-2 was shown to interact with connexin-43, the predominant connexin in epithelial and most other tissues which is involved in cell growth control and embryonic development. For immunisation of the guinea pig, amino acids 411-467 of human ZO-2 were used as immunogen. The antibody cross reacts with mouse ZO-2. |
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| Immunogen | n/a |
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| Other Names | Tight junction protein 2 (TJP2) |
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| Gene, Accession # | n/a |
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| Catalog # | HP9046 |
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| Order / More Info | ZO-2, Human Antibody from HYCULT BIOTECH |
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| Product Specific References | n/a |
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