| 产品详情 |
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| Antigenic Specificity | Fbxw7/Cdc4 |
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| Clone | FBOX 3a9/1 |
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| Host Species | Mouse |
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| Reactive Species | mouse, human |
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| Isotype | IgG1 |
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| Format | peroxidase (HRP) conjugate |
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| Size | 50ul |
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| Concentration | 1mg/ml |
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| Applications | IHC-P, IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mouse anti Fbxw7/Cdc4 [FBOX 3a9/1]: Horseradish peroxidase (HRP). This antibody recognises F-box/WD repeat-containing protein 7 (Fbxw7), which is also known as cdc4 and SEL-10. The FBW7/Cdc4 F-box protein was first recognized by its ability to bind cyclin E and the SCF (FBW7) is now known to target c-Myc, c-Jun and Notch for degradation in addition to its role in cyclin E proteolysis. FBW7 negatively regulates several key oncoproteins and is a tumour suppressor that is mutated in a wide spectrum of human cancers. |
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| Immunogen | Synthetic peptide of human sequence |
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| Other Names | AGO; Archipelago homolog; archipelago, Drosophila, homolog of; CDC4; DKFZp686F23254; F-box and WD repeat domain containing 7; F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila); F-box and WD-40 domain-containing protein 7; F-box protein FBW7; F-box protein FBX30; F-box protein SEL-10; F-box/WD repeat-containing protein 7; FBW6; FBW7; FBX30; FBXO30; FBXW6; FBXW7; FLJ16457; hAgo; hCdc4; homolog of C elegans sel-10; SEL-10; SEL10 |
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| Gene, Accession # | n/a |
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| Catalog # | IQ622HRP |
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| Price | |
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| Order / More Info | Fbxw7/Cdc4 Antibody from IMMUQUEST LTD. |
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| Product Specific References | Nateri AS, et al. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science. 2004.303(5662):1374-8. PMID:14739463 http://www.ncbi.nlm.nih.gov/pubmed/14739463 |
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