| 产品详情 |
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| Antigenic Specificity | Beta catenin |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | 100ul |
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| Concentration | 1ug/ul |
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| Applications | WB, IHC-P, IF(IHC-P), IF(ICC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Beta catenin Polyclonal Antibody. • Target Background: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt respon |
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| Immunogen | KLH conjugated synthetic peptide derived from human Beta catenin. Immunogen Range: 650-700/781 |
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| Other Names | CTNNB; MRD19; armadillo; Catenin beta-1; Beta-catenin; CTNNB1; OK/SW-cl.35; PRO2286 |
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| Gene, Accession # | Gene ID: 1499, SwissProt: P35222 |
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| Catalog # | bs-1165R |
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| Price | |
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| Order / More Info | Beta catenin Antibody from BIOSS ANTIBODIES |
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| Product Specific References | Zhang, Qiangling, et al. (2015) Int. J. Mol. Sci., 16, 17734-17745. PubMed: 26247931 // Lu, Juan, et al. (2015) Acta Odontol Scand. PubMed: 26414930 // Yang, Ruicheng, et al.(2016) Oncotarget. PubMed: 27588479 // Hu, Jianguo, et al. (2015) Oncotarget 6.14:12174. PubMed: 25895127 // Zheng, Jian, et al. (2016) J Neurosurg. PubMed: 27739937 // Zhu, Afang, et al. (2017) Biochem Biophys Res Commun. PubMed: 28870803 // Qi et al. (2016) Peer. 4:e2624. PubMed: 27833804 // Zou et al. (2018) EBioMedicine. 31:287-298. PubMed: 29764768 |
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