| 产品详情 |
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| Antigenic Specificity | beta Catenin 1 |
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| Clone | 12F7 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1, κ |
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| Format | purified, azide-free |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF), IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Ultra-LEAF™ Purified anti-β Catenin 1 (CTNNB1). β-catenin is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. β-catenin also plays a key role in Wnt signaling pathways and thus is involved in neural differentiation, synaptic plasticity, neurodegenerative disease, and prevention of apoptosis. Finally, this protein binds to the product of the adenomatous polyposis coli (APC) gene, which is mutated in the adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. |
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| Immunogen | Recombinant β-catenin (N-terminal fragment) fused to MBP. |
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| Other Names | Catenin (Cadherin-Associated Protein), Beta 1, 88 kD, CTNNB1, TNNB, MRD19, armadillo, catenin beta-1 |
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| Gene, Accession # | Gene ID: 1499 |
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| Catalog # | 844603 |
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| Price | |
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| Order / More Info | beta Catenin 1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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