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| Product Name | TPMT, 1-245aa, Human, E Coli |
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| Description | MW: 28 kDa (245 aa), confirmed by MALDI-TOF. Purity >95% by SDS-PAGE. TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal |
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| Size | 0.1 mg, 0.5 mg |
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| Concentration | 1 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [Thiopurine S-methyltransferase; Thiopurine S-methyltransferase; TPMT; Thiopurine S-methyltransferase HGNC:12014; S adenosyl L methionine thiopurine S methyltransferase; Thiopurine methyltransferase; Thiopurine S methyltransferase.] |
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| Gene, Accession, CAS # | TPMT, Gene ID: 7172, Accession: AAH05339 |
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| Catalog # | MBS203112 |
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| Order / More Info | TPMT, 1-245aa, Human, E Coli from MYBIOSOURCE INC. |
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| Product Specific References | Tai HL., et al. (1997) Proc Natl Acad Sci uSA. 94:6444-9.; Odani S., et al. (2001) J Biochem. 129 (2):213-9.; |
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