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| Product Name | Glutamic Acid Decarboxylase 67, Recombinant, Mouse, His-Tag, Positive Control for Western Blot |
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| Description | Highly Purified (~95%). Gamma Aminobutyric acid (GABA) is the major known inhibitory neurotransmitter. The rate-limiting step in the synthesis of GABA is the decarboxylation of glutamate by glutamate decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.115). In the CNS GAB is entirely restricted to GABAergic neurons. GAD is also present in the b-cells of the pancreas and autoantibodies to various GAD polypeptides are detected in insulin-dependent diabetes mellitus. Cloning of GAD genes have identified two subtypes: GAD65 (65kD; human 585aa chromosome 10) and GAD67 (67kD; human 594aa, chromosome 2) share approx. 65% amino acid homology. The N-terminus is the most divergent while the C-terminus is highly conserved. Although both GAD isoforms catalyzes the conversion of GABA but interact differently with the co-factor pyridoxal 5'- phosphate suggesting their activities are differentially regulated. GAD67 is cytosolic, while GAD65 is membrane associated. GAD65 is a major autoantigen in |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | Glutamic Acid Decarboxylase 67, Recombinant, Mouse, His-Tag, Positive Control for Western Blot (GAD67, GAD1) |
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| Gene, Accession, CAS # | Accession: BC027059 |
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| Catalog # | 208919 |
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| Order / More Info | Glutamic Acid Decarboxylase 67, Recombinant, Mouse, His-Tag, Positive Control for Western Blot from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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