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| Product Name | KITLG, Recombinant, Human, aa26-189, GST-Tag (Kit Ligand) |
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| Description | Purity ~90% (SDS-PAGE). Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Source: Recombinant protein corresponding to aa26-189 from human KITLG, fused to GST-Tag at N-termi |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mast cell growth factor, MGFStem cell factor, SCFc-Kit ligand |
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| Gene, Accession, CAS # | SwissProt: P21583 |
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| Catalog # | 373922 |
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| Order / More Info | KITLG, Recombinant, Human, aa26-189, GST-Tag (Kit Ligand) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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